Anti-Corin antibody,Abcam,AB232842

Host

Rabbit

Reactivity

Mouse, Human

Application

WB, IHC-P

Platform ID

BAB205034623

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Corin antibody
Cat. No.AB232842
HostRabbit
IsotypeIgG
ReactivityMouse, Human
ApplicationWB, IHC-P
ClonalityPolyclonal
Concentration0.23 - 0.76 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human CORIN aa 50-150. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) and brain natriuretic peptide (NPPB) processing (PubMed : 10880574, PubMed : 20489134, PubMed : 21288900, PubMed : 21763278). Converts through proteolytic cleavage the non-functional propeptides NPPA and NPPB into their active hormones, ANP and BNP(1-32) respectively, thereby regulating blood pressure in the heart and promoting natriuresis, diuresis and vasodilation (PubMed : 10880574, PubMed : 20489134, PubMed : 21288900, PubMed : 21763278). Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus (PubMed : 22437503). Also acts as a regulator of sodium reabsorption in kidney (By similarity).. Isoform 2. Has weaker endopeptidase activity compared to isoform 1. See full target information CORIN

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.