Anti-Cytochrome C antibody [37BA11],Abcam,AB110325

What is this antibody validated in? Anti-Cytochrome C antibody [37BA11] (ab110325) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Flow Cyt), Immunocytochemistry/immunofluorescence (ICC/IF) in Caenorhabditis elegans, Cow, Human, Mouse, Rat samples. What is the molecular weight of Cytochrome C? Anti-Cytochrome C [37BA11] (ab110325) specifically detects a band for Cytochrome C (UniProt: P99999) at a molecular weight of 12kDa. Trusted by the scientific community Anti-Cytochrome C [37BA11] (ab110325) was first used in a scientific publication in 2011 and has been cited over 130 times in peer-reviewed journals. Other related products We have a range of other formats of antibody clone [37BA11] also available for your convenience: ab110325, Alexa Fluor® 488 - ab154476 , HRP - ab198489 , Alexa Fluor® 647 - ab198583 Want a custom formulation? This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact [email protected]

Host

Mouse

Reactivity

Mouse, Rat, Cow, Human, Caenorhabditis elegans

Application

Flow Cyt, ICC/IF, WB

Platform ID

BAB837943325

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Cytochrome C antibody [37BA11]
Cat. No.AB110325
HostMouse
IsotypeIgG2a
ReactivityMouse, Rat, Cow, Human, Caenorhabditis elegans
ApplicationFlow Cyt, ICC/IF, WB
ClonalityMonoclonal
Clone Number37BA11
Concentration1 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein G
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 - 7.5 Preservative: 0.02% Sodium azide Constituents: HEPES buffered saline
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. See full target information CYCS

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