Anti-DDB2 antibody [2246C4a],Abcam,AB51017

Target data Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (PubMed : 10882109, PubMed : 11278856, PubMed : 11705987, PubMed : 12732143, PubMed : 15882621, PubMed : 16473935, PubMed : 18593899, PubMed : 32789493, PubMed : 9892649). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (PubMed : 10882109, PubMed : 11278856, PubMed : 11705987, PubMed : 12944386, PubMed : 14751237, PubMed : 16260596, PubMed : 32789493). The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches (PubMed : 10882109, PubMed : 11278856, PubMed : 11705987, PubMed : 12944386, PubMed : 16260596). Also functions as the substrate recognition module for the DCX (DDB2-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB2-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1) (PubMed : 12732143, PubMed : 15882621, PubMed : 16473935, PubMed : 18593899, PubMed : 26572825). The DDB2-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage (PubMed : 16473935, PubMed : 16678110). The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (PubMed : 16473935, PubMed : 16678110). The DDB2-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (PubMed : 15882621). The DDB2-CUL4-ROC1 complex also ubiquitinates KAT7/HBO1 in response to DNA damage, leading to its degradation : recognizes KAT7/HBO1 following phosphorylation by ATR (PubMed : 26572825).. Isoform D1. Inhibits UV-damaged DNA repair.. Isoform D2. Inhibits UV-damaged DNA repair. See full target information DDB2