Anti-DGKZ/DGK-zeta antibody [EPR22040-72],Abcam,AB239080

Target data Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed : 15544348, PubMed : 18004883, PubMed : 19744926, PubMed : 22108654, PubMed : 22627129, PubMed : 23949095, PubMed : 9159104). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed : 15544348, PubMed : 18004883, PubMed : 19744926, PubMed : 22108654, PubMed : 22627129, PubMed : 23949095, PubMed : 9159104). Also plays an important role in the biosynthesis of complex lipids (Probable). Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species (PubMed : 19744926, PubMed : 22108654, PubMed : 9159104). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group (PubMed : 15544348, PubMed : 19744926, PubMed : 22627129). The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol (By similarity). By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization (PubMed : 15157668). Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane (By similarity).. Isoform 1. Regulates RASGRP1 activity.. Isoform 2. Does not regulate RASGRP1 activity. See full target information DGKZ