Anti-DHHC-12 antibody,Abcam,AB237688

Host

Rabbit

Reactivity

Human, Mouse, Rat

Application

IHC-P, WB

Platform ID

BAB719177831

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-DHHC-12 antibody
Cat. No.AB237688
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse, Rat
ApplicationIHC-P, WB
ClonalityPolyclonal
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human ZDHHC12 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed : 36586411). Has a palmitoyltransferase activity toward gephyrin/GPHN, regulating its clustering at synapses and its function in gamma-aminobutyric acid receptor clustering (By similarity). Thereby, indirectly regulates GABAergic synaptic transmission (By similarity). Acts as an inhibitor of the NLRP3 inflammasome by mediating palmitoylation of NLRP3, thereby promoting NLRP3 degradation by the chaperone-mediated autophagy (CMA) process (PubMed : 36586411). See full target information ZDHHC12

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