Anti-DLL4 antibody [MHD4-46],Abcam,AB270620

Host

Mouse

Application

Flow Cyt

Platform ID

BAB283008442

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-DLL4 antibody [MHD4-46]
Cat. No.AB270620
HostMouse
IsotypeIgG1
ApplicationFlow Cyt
ClonalityMonoclonal
Clone NumberMHD4-46
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Full Length Protein corresponding to Human DLL4.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.1% Sodium azide
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Involved in the Notch signaling pathway as Notch ligand (PubMed : 11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed : 20616313). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate (PubMed : 17728344). See full target information DLL4

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