Anti-DNA Polymerase iota antibody,Abcam,AB264193

Host

Rabbit

Reactivity

Human

Application

IP, WB

Platform ID

BAB596114401

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-DNA Polymerase iota antibody
Cat. No.AB264193
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationIP, WB
ClonalityPolyclonal
Concentration0.2 mg/mL Batch dependent concentration
ImmunogenSynthetic Peptide within Human POLI aa 650 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: Tris buffered saline, 0.1% BSA
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Error-prone DNA polymerase specifically involved in DNA repair (PubMed : 11013228, PubMed : 11387224). Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed : 11013228, PubMed : 11387224, PubMed : 14630940, PubMed : 15199127). Favors Hoogsteen base-pairing in the active site (PubMed : 15254543). Inserts the correct base with high-fidelity opposite an adenosine template (PubMed : 15254543). Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine (PubMed : 11013228). May play a role in hypermutation of immunoglobulin genes (PubMed : 12410315). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (PubMed : 11251121, PubMed : 14630940). See full target information POLI

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