Anti-DNA Polymerase iota antibody [OTI1H9],Abcam,AB157244

The clone number has been updated from 1H9 to OTI1H9, both clone numbers name the same clone.

Host

Mouse

Reactivity

Human

Application

WB

Platform ID

BAB908620648

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-DNA Polymerase iota antibody [OTI1H9]
Cat. No.AB157244
HostMouse
IsotypeIgG1
ReactivityHuman
ApplicationWB
ClonalityMonoclonal
Clone NumberOTI1H9
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human POLI aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Error-prone DNA polymerase specifically involved in DNA repair (PubMed : 11013228, PubMed : 11387224). Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed : 11013228, PubMed : 11387224, PubMed : 14630940, PubMed : 15199127). Favors Hoogsteen base-pairing in the active site (PubMed : 15254543). Inserts the correct base with high-fidelity opposite an adenosine template (PubMed : 15254543). Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine (PubMed : 11013228). May play a role in hypermutation of immunoglobulin genes (PubMed : 12410315). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (PubMed : 11251121, PubMed : 14630940). See full target information POLI

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