Anti-DNAJB6 antibody,Abcam,AB96539

Host

Rabbit

Reactivity

Human

Application

ICC/IF, WB

Platform ID

BAB096364281

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-DNAJB6 antibody
Cat. No.AB96539
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationICC/IF, WB
ClonalityPolyclonal
Concentration0.46 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human DNAJB6 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70 (PubMed : 10954706, PubMed : 28233300). Plays an indispensable role in the organization of KRT8/KRT18 filaments (PubMed : 10954706). Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin (PubMed : 11896048, PubMed : 22366786). Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (PubMed : 20159555, PubMed : 22366786). Also reduces cellular toxicity and caspase-3 activity (PubMed : 11896048).. Isoform B. Isoform B but not isoform A inhibits huntingtin aggregation. See full target information DNAJB6

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