Anti-DR5 antibody [DR5-01-1],Abcam,AB166650
Host
Mouse
Reactivity
Human
Application
Flow Cyt
Platform ID
BAB660594700
Abcam
Contact
Tel: +44 (0)1223 696000
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Product Specifications
Scientific Background
Specifications
NameAnti-DR5 antibody [DR5-01-1]
Cat. No.AB166650
HostMouse
IsotypeIgG1
ReactivityHuman
ApplicationFlow Cyt
ClonalityMonoclonal
Clone NumberDR5-01-1
Concentration1 mg/mL Batch dependent concentration
ImmunogenFusion protein corresponding to TNFRSF10B, fused to IGG1_HUMAN and to TNFRSF10B. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.097% Sodium azide Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only
Scientific Background
Target data Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed : 10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. See full target information TNFRSF10B
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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