Anti-DUSP6 antibody [EPR129Y],Abcam,AB76310

Product Specifications Anti-DUSP6 antibody [EPR129Y] (ab76310) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), IHC-P, IP, WB in human, mouse, rat samples. Anti-DUSP6 antibody [EPR129Y] (ab76310) specifically detects DUSP6 (UniProt ID: Q16828; Molecular weight: 42kDa) and is sold in 100 µL and 1 mL selling sizes. Quality and Validation Abcam's high quality manufacturing and validation processes ensure Anti-DUSP6 antibody [EPR129Y] (ab76310) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-DUSP6 antibody [EPR129Y] (ab76310) has been confirmed by testing in knockout samples. Anti-DUSP6 antibody [EPR129Y] (ab76310) has been cited over 58 times in peer reviewed journals and is trusted by the scientific community. Anti-DUSP6 antibody [EPR129Y] (ab76310) has 16 independent reviews from customers. Related Products Antibody clone EPR129Y is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 594, PE, APC, HRP, Alkaline Phosphatase, Alexa Fluor® 488, Alexa Fluor® 647, Alexa Fluor® 555, Alexa Fluor® 568, Alexa Fluor® 750 ( ab207877 , ab305641 , ab305642 , ab305643 , ab308919 , ab309852 , ab310218 , ab312194 , ab312682 , ab321724 ). Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rabbit

Reactivity

Mouse, Rat, Human

Application

IP, IHC-P, Flow Cyt (Intra), WB

Platform ID

BAB911419304

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-DUSP6 antibody [EPR129Y]
Cat. No.AB76310
HostRabbit
IsotypeIgG
ReactivityMouse, Rat, Human
ApplicationIP, IHC-P, Flow Cyt (Intra), WB
ClonalityMonoclonal
Clone NumberEPR129Y
Concentration1.047 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases (PubMed : 8670865). Has a specificity for the ERK family (PubMed : 8670865). Plays an important role in alleviating chronic postoperative pain (By similarity). Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors (PubMed : 29043977). See full target information DUSP6

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