Anti-Desmin antibody [Y66] - Cytoskeleton Marker,Abcam,AB32362
Anti-Desmin antibody [Y66] - Cytoskeleton Marker (ab32362) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), ICC/IF, IHC-P, WB in guinea pig, human, mouse, rat samples. Anti-Desmin antibody [Y66] - Cytoskeleton Marker (ab32362) has been cited over 176 times in peer reviewed journals and is trusted by the scientific community. Abcams high quality manufacturing and validation processes ensure Anti-Desmin antibody [Y66] - Cytoskeleton Marker (ab32362) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-Desmin antibody [Y66] - Cytoskeleton Marker (ab32362) has 12 independent reviews from customers. Anti-Desmin antibody [Y66] - Cytoskeleton Marker (ab32362) specifically detects Desmin (UniProt ID: P17661; Molecular weight: 53kDa) and is sold in 100 uL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone Y66 - ab271829 . Antibody clone Y66 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488, Alexa Fluor® 647, HRP, Biotin, Alexa Fluor® 594, Alexa Fluor® 555, APC, PE ( ab18533 , ab195177 , ab195178 , ab19763 , ab23419 , ab23422 , ab224934 , ab224935 ). Desmin is a crucial muscle-specific type III intermediate filament protein essential for maintaining the structural integrity of muscle cells. Mutations in Desmin can lead to myopathy and cardiomyopathy, causing muscle weakness and heart disease. Utilizing Desmin as a biomarker can significantly aid in diagnosing these conditions and guiding treatment strategies. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Guinea pig, Human
Application
WB, Flow Cyt (Intra), ICC/IF, IHC-P
Platform ID
BAB030984414
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed : 25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed : 24200904, PubMed : 25394388, PubMed : 26724190). May act as a sarcomeric microtubule-anchoring protein : specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). See full target information DES
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