Anti-Dicer antibody [13D6] - ChIP Grade,Abcam,AB14601
What is this antibody validated in? Anti-Dicer antibody [13D6] - ChIP Grade (ab14601) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), ChIP in Human, Mouse samples. Trusted by the scientific community Anti-Dicer [13D6] - ChIP Grade (ab14601) was first used in a scientific publication in 2004 and has been cited over 150 times in peer-reviewed journals. Reviewed by scientists Anti-Dicer [13D6] - ChIP Grade (ab14601) has over 15 independent reviews from customers. Specificity confirmed The specificity of Anti-Dicer antibody [13D6] - ChIP Grade (ab14601) has been confirmed by Immunocytochemistry testing in DICER1 Knockout HAP1 cells.
Host
Mouse
Reactivity
Mouse, Human
Application
ChIP, Flow Cyt, WB
Platform ID
BAB344590133
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. See full target information DICER1
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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