Anti-Dkk3 antibody,Abcam,AB2459
Host
Goat
Reactivity
Human
Application
WB
Platform ID
BAB032683598
Abcam
Contact
Tel: +44 (0)1223 696000
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Product Specifications
Scientific Background
Specifications
NameAnti-Dkk3 antibody
Cat. No.AB2459
HostGoat
IsotypeIgG
ReactivityHuman
ApplicationWB
ClonalityPolyclonal
Concentration0.5 mg/mL Batch dependent concentration
ImmunogenSynthetic Peptide within Human DKK3 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA
Storage-20°C
Regulatory StatusResearch Use Only
Scientific Background
Target data Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). See full target information DKK3
Category Paths
- Products>Primary Antibodies>Polyclonal Antibodies
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