Anti-Dnmt3a antibody [EPR18455],Abcam,AB188470
What is this antibody validated in? Anti-Dnmt3a antibody [EPR18455] (ab188470) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse, Rat samples. What is the molecular weight of Dnmt3a? Anti-Dnmt3a [EPR18455] (ab188470) specifically detects a band for Dnmt3a (UniProt: Q9Y6K1) at a molecular weight of 102kDa. Trusted by the scientific community Anti-Dnmt3a [EPR18455] (ab188470) was first used in a scientific publication in 2015 and has been cited over 30 times in peer-reviewed journals. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-Dnmt3a antibody [EPR18455] (ab188470) has been confirmed by Western blot testing in DNMT3A Knockout HAP1 cell line, ab261793 . Other related products We have a range of other formats of antibody clone [EPR18455] also available for your convenience: ab188470, Carrier free - ab232391 , Carrier free - ab300008, PE - ab305716 , APC - ab305717 , HRP - ab305718 , Alkaline Phosphatase - ab308817 , Alexa Fluor® 488 - ab309762 , Alexa Fluor® 647 - ab310130 , Alexa Fluor® 594 - ab310548 , Alexa Fluor® 555 - ab312078 , Alexa Fluor® 568 - ab312555 , Alexa Fluor® 750 - ab321309 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
WB, IHC-P, ICC/IF, ChIC/CUT&RUN-seq, Flow Cyt (Intra)
Platform ID
BAB284407770
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development (PubMed : 12138111, PubMed : 16357870, PubMed : 30478443). DNA methylation is coordinated with methylation of histones (PubMed : 12138111, PubMed : 16357870, PubMed : 30478443). It modifies DNA in a non-processive manner and also methylates non-CpG sites (PubMed : 12138111, PubMed : 16357870, PubMed : 30478443). May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (By similarity). Plays a role in paternal and maternal imprinting (By similarity). Required for methylation of most imprinted loci in germ cells (By similarity). Acts as a transcriptional corepressor for ZBTB18 (By similarity). Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (By similarity). Can actively repress transcription through the recruitment of HDAC activity (By similarity). Also has weak auto-methylation activity on Cys-710 in absence of DNA (By similarity). See full target information DNMT3A
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
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