Anti-Dnmt3b antibody,Abcam,AB2851
What is this antibody validated in? Anti-Dnmt3b antibody (ab2851) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P) in Human, Mouse samples. What is the molecular weight of Dnmt3b? Anti-Dnmt3b (ab2851) specifically detects a band for Dnmt3b (UniProt: O88509) at a molecular weight of 97.5kDa. Trusted by the scientific community Anti-Dnmt3b (ab2851) was first used in a scientific publication in 2003 and has been cited over 130 times in peer-reviewed journals. Reviewed by scientists Anti-Dnmt3b (ab2851) has over 5 independent reviews from customers.
Host
Rabbit
Reactivity
Mouse, Human
Application
IHC-P, WB
Platform ID
BAB972001475
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Functions as a transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells (PubMed : 27153398). See full target information DNMT3B
Category Paths
- Products>Primary Antibodies>Polyclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
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