Anti-Drosophila FMR1 antibody [6A15],Abcam,AB10299
Fragile X syndrome is the most common inherited form of mental retardation. It is caused by loss of FMR1 gene activity due to either lack of expression or expression of a mutant form of the protein. In mammals, FMR1 is a member of a small protein family that consists of FMR1, FXR1, and FXR2. All three members bind RNA and contain sequence motifs that are commonly found in RNA-binding proteins, including two KH domains and an RGG box.The Drosophila genome contains a single gene homologous to the FXR family. dFMR1 is subjected to transcriptional and posttranscriptional regulation during development and it homomerizes, like its human counterpart. dFMR1 profile of expression recapitulates that of the human FXR protein family: it is highly enriched in muscles, in central nervous system and in gonads. In the larval brain, anti-dFMR1 also recognizes mushroom bodies, a centre that mediates learning and memory. These features make the fly an ideal system to analyse the role of the FXR family and to identify genes in the FMRP pathway.
Host
Mouse
Reactivity
Drosophila melanogaster
Application
WB, ICC/IF, ELISA, IP
Platform ID
BAB035982014
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Polyribosome-associated RNA-binding protein that plays a role in neuronal development and synaptic plasticity through the regulation of protein synthesis of mRNAs (PubMed : 11046149, PubMed : 11733059, PubMed : 12368261, PubMed : 17178403). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment : undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed : 35165263). Mainly acts as an activator of mRNA translation : promotes translation of stored mRNAs in oocytes (PubMed : 30115809). Can also act as a negative translational regulator of specific mRNAs (PubMed : 11733059, PubMed : 17178403). Represses translation of the microtubule-associated protein futsch mRNA to regulate microtubule-dependent synaptic growth and function (PubMed : 11733059). Localizes to specific N6-methyladenosine (m6A)-containing RNAs as part of a complex with the m6A reader Ythdf and thereby regulates axonal growth in the mushroom bodies and neuromuscular junctions (PubMed : 33428246). Specifically recognizes and binds a subset of N6-methyladenosine (m6A)-containing mRNAs in embryos, promoting formation of a phase-separated membraneless compartment that mediates degradation of maternal mRNAs (PubMed : 35165263). May also be involved in microRNA (miRNA)-mediated translational suppression as part of the RNA-induced silencing complex (RISC) (PubMed : 12368261, PubMed : 14508492). Required for stability of the central pair of microtubules in the spermatid axoneme (PubMed : 15183715). Regulates photoreceptor structure and neuromuscular junction (NMJ) neurotransmission in the eye (PubMed : 11733059, PubMed : 17178403). During embryogenesis, involved in germline fate determination (PubMed : 16949822). See full target information Fmr1
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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