Anti-E Cadherin antibody [4A2],Abcam,AB231303
Product Specifications Anti-E Cadherin antibody [4A2] (ab231303) is a mouse monoclonal antibody and is validated for use in ICC/IF, IHC-P, WB in human, mouse, rat samples. Anti-E Cadherin antibody [4A2] (ab231303) specifically detects E Cadherin (UniProt ID: P12830; Molecular weight: 80kDa) and is sold in 100 µg selling sizes. Quality and Validation Abcam's high quality validation processes ensure Anti-E Cadherin antibody [4A2] (ab231303) has high sensitivity and specificity. The specificity of Anti-E Cadherin antibody [4A2] (ab231303) has been confirmed by testing in knockout samples. Anti-E Cadherin antibody [4A2] (ab231303) has been cited over 140 times in peer reviewed journals and is trusted by the scientific community. Related Products Conjugation-ready, carrier free format available for antibody clone 4A2 - ab233766 . Want a custom formulation? This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact [email protected]
Host
Mouse
Reactivity
Mouse, Rat, Human
Application
WB, IHC-P, ICC/IF
Platform ID
BAB724675191
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data CDH1 encodes a protein that is a calcium-dependent cell adhesion molecule, playing a role in cell-cell adhesion, mobility, and proliferation in epithelial cells. It acts as a potent invasive suppressor and serves as a ligand for integrin alpha-E/beta-7. The protein contributes to the sorting of heterogeneous cell types due to its homophilic interactions. E-Cad/CTF2, a product of CDH1, promotes the non-amyloidogenic degradation of Abeta precursors and strongly inhibits the production of APP C99 and C83. Additionally, in the context of microbial infection, it functions as a receptor for Listeria monocytogenes, with internalin A binding to it to promote bacterial uptake. This supplementary information is collated from multiple sources and compiled automatically. See full target information CDH1
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
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