Anti-E Cadherin antibody [DECMA-1] - Intercellular Junction Marker,Abcam,AB11512
What is this antibody validated in? Anti-E Cadherin antibody [DECMA-1] - Intercellular Junction Marker (ab11512) is a rat monoclonal antibody and is validated for use in Immunocytochemistry/immunofluorescence (ICC/IF) in Mouse samples. Trusted by the scientific community Anti-E Cadherin [DECMA-1] - Intercellular Junction Marker (ab11512) was first used in a scientific publication in 2004 and has been cited over 140 times in peer-reviewed journals. Reviewed by scientists Anti-E Cadherin [DECMA-1] - Intercellular Junction Marker (ab11512) has over 25 independent reviews from customers. Other related products We have a range of other formats of antibody clone [DECMA-1] also available for your convenience: ab11512, Carrier free - ab264106 Want a custom formulation? This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact [email protected]
Host
Rat
Reactivity
Mouse
Application
ICC/IF
Platform ID
BAB912218920
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Cadherins are calcium-dependent cell adhesion proteins (PubMed : 11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed : 11976333). Promotes organization of radial actin fiber structure and cellular response to contractile forces, via its interaction with AMOTL2 which facilitates anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane (By similarity). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 (By similarity).. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production (By similarity).. (Microbial infection) Does not function as a receptor for L.monocytogenes internalin A (InlA); mutating a single surface-exposed residue confers receptor activity to this protein and promotes uptake of the bacteria. See full target information Cdh1
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
Please provide the required information below so that we can quickly source your products.