Anti-EED antibody [163C],Abcam,AB126542

Host

Mouse

Reactivity

Mouse, Human

Application

ICC, IHC-P, ICC/IF

Platform ID

BAB851236941

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-EED antibody [163C]
Cat. No.AB126542
HostMouse
IsotypeIgG2a
ReactivityMouse, Human
ApplicationICC, IHC-P, ICC/IF
ClonalityMonoclonal
Clone Number163C
ImmunogenRecombinant Full Length Protein corresponding to Human EED.
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.02% Sodium azide
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. See full target information EED

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