Anti-EPO-R antibody [016],Abcam,AB275686

Host

Rabbit

Reactivity

Human

Application

WB

Platform ID

BAB794452946

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-EPO-R antibody [016]
Cat. No.AB275686
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationWB
ClonalityMonoclonal
Clone Number016
ImmunogenRecombinant Fragment Protein within Human EPOR aa 1-250. The exact immunogen used to generate this antibody is proprietary information.
Regulatory StatusResearch Use Only

Scientific Background

Target data Receptor for erythropoietin, which mediates erythropoietin-induced erythroblast proliferation and differentiation (PubMed : 10388848, PubMed : 2163695, PubMed : 2163696, PubMed : 8662939, PubMed : 9774108). Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade (By similarity). In some cell types, can also activate STAT1 and STAT3 (PubMed : 11756159). May also activate the LYN tyrosine kinase (By similarity).. Isoform EPOR-T. Acts as a dominant-negative receptor of EPOR-mediated signaling. See full target information EPOR

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