Anti-ETAA1 antibody,Abcam,AB122245

Host

Rabbit

Reactivity

Human

Application

IHC-P, WB

Platform ID

BAB359283077

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-ETAA1 antibody
Cat. No.AB122245
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationIHC-P, WB
ClonalityPolyclonal
Concentration0.4 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human ETAA1 aa 350-500. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity (PubMed : 27601467, PubMed : 27723717, PubMed : 27723720). Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 (PubMed : 27723717, PubMed : 27723720, PubMed : 30139873). Probably only regulates a subset of ATR targets (PubMed : 27723717, PubMed : 27723720). See full target information ETAA1

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