Anti-Endothelin 1 antibody,Abcam,AB117757
What is this antibody validated in? Anti-Endothelin 1 antibody (ab117757) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P) in Human, Mouse samples. What is the molecular weight of Endothelin 1? Anti-Endothelin 1 (ab117757) specifically detects a band for Endothelin 1 (UniProt: P05305) at a molecular weight of 24kDa. Trusted by the scientific community Anti-Endothelin 1 (ab117757) was first used in a scientific publication in 2011 and has been cited over 20 times in peer-reviewed journals.
Host
Rabbit
Reactivity
Mouse, Human
Application
IHC-P, ICC, WB
Platform ID
BAB229922671
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (PubMed : 19086031). Also binds the DEAR/FBXW7-AS1 receptor (PubMed : 17446437). Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with F-actin filaments (By similarity). NFATC3 then translocates to the nucleus where it subsequently promotes the transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). See full target information EDN1
Category Paths
- Products>Primary Antibodies>Polyclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
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