Anti-ErbB2 / HER2 antibody [SP3],Abcam,AB16662
This product was switched from a hybridoma to recombinant production method on 5th March 2019. Product Specifications Anti-ErbB2 / HER2 antibody [SP3] (ab16662) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in IHC-P in human samples. Anti-ErbB2 / HER2 antibody [SP3] (ab16662) specifically detects ErbB2 / HER2 (UniProt ID: P04626; Molecular weight: 136kDa) and is sold in 100 µL, 500 µL and 1 mL selling sizes. Anti-ErbB2 / HER2 antibody [SP3] (ab16662) is a clone from the portfolio of Spring Bioscience (Roche) SP clones which have been optimised for immunohistochemistry (IHC). Quality and Validation Abcam's high quality manufacturing and validation processes ensure Anti-ErbB2 / HER2 antibody [SP3] (ab16662) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Related Products Antibody clone SP3 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488, Alexa Fluor® 647 ( ab270190 , ab270191 ). Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Human
Application
IHC-P
Platform ID
BAB482446459
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data The protein expressed by the ERBB2 gene is a protein tyrosine kinase involved in several cell surface receptor complexes, requiring a coreceptor for ligand binding. It is an essential component of a neuregulin-receptor complex, although neuregulins do not bind to it directly. GP30 is a potential ligand for this receptor. ERBB2 regulates the outgrowth and stabilization of peripheral microtubules (MTs) via the MEMO1-RHOA-DIAPH1 signaling pathway, which, upon activation, phosphorylates and inhibits GSK3B at the cell membrane. This prevents APC and CLASP2 phosphorylation, allowing their association with the cell membrane, facilitating MACF1 localization necessary for microtubule capture and stabilization. In the nucleus, ERBB2 is involved in transcriptional regulation, associating with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter to activate transcription. It is implicated in the transcriptional activation of CDKN1A, involving STAT3 and SRC, and participates in the transcription of rRNA genes by RNA Pol I, thereby enhancing protein synthesis and cell growth. This supplementary information is collated from multiple sources and compiled automatically. See full target information ERBB2
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
- Products>Trial Size Antibodies
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