Anti-Estrogen Related Receptor alpha antibody,Abcam,AB137489

Host

Rabbit

Reactivity

Mouse, Rat, Human

Application

ChIP, IHC-P, ICC/IF, IP, WB

Platform ID

BAB546726854

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Estrogen Related Receptor alpha antibody
Cat. No.AB137489
HostRabbit
IsotypeIgG
ReactivityMouse, Rat, Human
ApplicationChIP, IHC-P, ICC/IF, IP, WB
ClonalityPolyclonal
Concentration1.68 mg/mL Batch dependent concentration
ImmunogenSynthetic Peptide within Human ESRRA aa 1-50. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle. See full target information ESRRA

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