Anti-Exonuclease 1 antibody,Abcam,AB155553

Host

Rabbit

Reactivity

Mouse, Human

Application

ICC/IF, WB

Platform ID

BAB672289084

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Exonuclease 1 antibody
Cat. No.AB155553
HostRabbit
IsotypeIgG
ReactivityMouse, Human
ApplicationICC/IF, WB
ClonalityPolyclonal
Concentration0.83 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human EXO1 aa 450-800. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. See full target information EXO1

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.