Anti-Exportin 4/XPO4 antibody [EPR4442(2)],Abcam,AB133237

Target data Mediates the nuclear export of proteins (cargos), such as EIF5A, SMAD3 and isoform M2 of PKM (PKM2) (PubMed : 10944119, PubMed : 16449645, PubMed : 26787900). In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins (PubMed : 10944119, PubMed : 16449645). Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor (PubMed : 10944119, PubMed : 16449645). XPO4 then return to the nuclear compartment and mediate another round of transport (PubMed : 10944119, PubMed : 16449645). The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed : 10944119, PubMed : 16449645). Catalyzes the nuclear export of hypusinated EIF5A; a small cytoplasmic protein that enters nucleus and accumulates within nucleolus if not exported back by XPO4 (PubMed : 10944119). Specifically mediates nuclear export of isoform M2 of PKM (PKM2) following PKM2 deacetylation by SIRT6 (PubMed : 26787900). Also mediates the nuclear import of SOX transcription factors SRY and SOX2 (By similarity). See full target information XPO4