Anti-FBXL3 antibody,Abcam,AB96645

Host

Rabbit

Reactivity

Mouse, Human

Application

WB, ICC/IF

Platform ID

BAB425662464

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-FBXL3 antibody
Cat. No.AB96645
HostRabbit
IsotypeIgG
ReactivityMouse, Human
ApplicationWB, ICC/IF
ClonalityPolyclonal
Concentration0.41 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human FBXL3 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation (PubMed : 17463251, PubMed : 23452855, PubMed : 27565346). The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2 (PubMed : 17463251, PubMed : 23452855, PubMed : 27565346). Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex (PubMed : 23452855). See full target information FBXL3

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