Anti-FE65 antibody [EPR3538],Abcam,AB91650

Target data Transcription coregulator that can have both coactivator and corepressor functions (PubMed : 15031292, PubMed : 18468999, PubMed : 18922798, PubMed : 25342469, PubMed : 33938178). Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain (PubMed : 15031292, PubMed : 18468999, PubMed : 18922798, PubMed : 25342469). Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis (PubMed : 15031292, PubMed : 18468999, PubMed : 18922798, PubMed : 25342469). May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1 (PubMed : 19234442). Required for histone H4 acetylation at double-strand breaks (DSBs) (PubMed : 19234442). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity (PubMed : 33938178). Functions in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4 (PubMed : 19343227). Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed : 19343227). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity). Plays a role in the maintenance of lens transparency (By similarity). May play a role in muscle cell strength (By similarity). Acts as a molecular adapter that functions in neurite outgrowth by activating the RAC1-ARF6 axis upon insulin treatment (PubMed : 36250347). See full target information APBB1