Anti-FN3K antibody [HL2223],Abcam,AB317168

Host

Rabbit

Reactivity

Human, Mouse, Rat

Application

IHC-P, WB

Platform ID

BAB371277317

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-FN3K antibody [HL2223]
Cat. No.AB317168
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse, Rat
ApplicationIHC-P, WB
ClonalityMonoclonal
Clone NumberHL2223
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human FN3K.
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate (PubMed : 11016445, PubMed : 11522682, PubMed : 11975663). Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (PubMed : 11522682, PubMed : 11975663). Involved in intracellular deglycation in erythrocytes (PubMed : 11975663). Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function (By similarity). Also able to phosphorylate psicosamines and ribulosamines (PubMed : 14633848). See full target information FN3K

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