Anti-FOXA2 antibody [EPR4466],Abcam,AB108422
Anti-FOXA2 antibody [EPR4466] (ab108422) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in ICC/IF, IHC-P, WB in human, mouse samples. Anti-FOXA2 antibody [EPR4466] (ab108422) has been cited over 104 times in peer reviewed journals and is trusted by the scientific community. Abcams high quality manufacturing and validation processes ensure Anti-FOXA2 antibody [EPR4466] (ab108422) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-FOXA2 antibody [EPR4466] (ab108422) has 11 independent reviews from customers. Anti-FOXA2 antibody [EPR4466] (ab108422) specifically detects FOXA2 (UniProt ID: Q9Y261; Molecular weight: 48kDa) and is sold in 100 uL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone EPR4466 - ab2281 . Antibody clone EPR4466 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488, Alexa Fluor® 647, HRP, Alexa Fluor® 594, Alexa Fluor® 568, Alexa Fluor® 555, Alexa Fluor® 75 ( ab193864 , ab193879 , ab19388 , ab311752 , ab31332 , ab313233 , ab3292 ). FOXA2 is a pivotal transcription factor involved in the regulation of liver development and lung development. Research has shown that FOXA2 plays a significant role in various cancers, including liver and lung cancers. Understanding FOXA2's function can provide insights into developmental biology and potential therapeutic targets for cancer treatment. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Human
Application
IHC-P, ICC/IF, WB
Platform ID
BAB121752089
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. See full target information FOXA2
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
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