Anti-Fibronectin antibody,Abcam,AB2413
Anti-Fibronectin antibody (ab2413) is a rabbit polyclonal antibody and is validated for use in ICC/IF, IHC-P, WB in human samples. Anti-Fibronectin antibody (ab2413) has been cited over 977 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-Fibronectin antibody (ab2413) has high sensitivity and specificity. Anti-Fibronectin antibody (ab2413) has 89 independent reviews from customers. Anti-Fibronectin antibody (ab2413) specifically detects Fibronectin (UniProt ID: P02751; Molecular weight: 269kDa) and is sold in 250 µL selling sizes. Fibronectin (FN1) is a glycoprotein that plays a critical role in the extracellular matrix (ECM) and is significantly upregulated in the tumor microenvironment. Fibronectin (FN1) facilitates tumor angiogenesis, providing essential nutrients to the growing tumor. It also aids in cancer cell invasion and metastasis through interactions with integrins and activation of signaling pathways like FAK/MAPK/ERK and Wnt. Additionally, fibronectin is involved in the epithelial-mesenchymal transition (EMT), which enhances the migratory and invasive capabilities of cancer cells.
Host
Rabbit
Reactivity
Mouse, Human
Application
WB, ICC/IF, IHC-P
Platform ID
BAB115954873
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin (PubMed : 3024962, PubMed : 3593230, PubMed : 3900070, PubMed : 7989369). Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (PubMed : 3024962, PubMed : 3593230, PubMed : 3900070, PubMed : 7989369). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation (PubMed : 34089617).. Anastellin. Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.. Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5 : ITGB1 integrin receptor signaling. See full target information FN1
Category Paths
- Products>Primary Antibodies>Polyclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
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