Anti-Fibronectin antibody [EPR19241-46],Abcam,AB199056
What is this antibody validated in? Anti-Fibronectin antibody [EPR19241-46] (ab199056) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Mouse, Rat samples. What is the molecular weight of Fibronectin? Anti-Fibronectin [EPR19241-46] (ab199056) specifically detects a band for Fibronectin (UniProt: P11276) at a molecular weight of 273kDa. Trusted by the scientific community Anti-Fibronectin [EPR19241-46] (ab199056) was first used in a scientific publication in 2017 and has been cited over 10 times in peer-reviewed journals. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Other related products We have a range of other formats of antibody clone [EPR19241-46] also available for your convenience: ab199056, Carrier free - ab224689 , Alexa Fluor® 488 - ab237286 , Alexa Fluor® 647 - ab237287 , Carrier free - ab242781 , Alexa Fluor® 568 - ab314284 , Biotin - ab322832 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat
Application
WB, Flow Cyt (Intra), IHC-P, IP, ICC/IF
Platform ID
BAB990992355
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin (By similarity). Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape healing, and maintenance of cell shape (By similarity). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (PubMed : 21768292). Participates in the regulation of type I collagen deposition by osteoblasts (PubMed : 21768292). Acts as a ligand for the Lilrb4a receptor, inhibiting Fcgr1/CD64-mediated monocyte activation (PubMed : 34089617).. Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5 : ITGB1 integrin receptor signaling.. Anastellin. Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling. See full target information Fn1
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