Anti-Fibronectin antibody [EPR23110-46],Abcam,AB268020
Anti-Fibronectin antibody [EPR23110-46] (ab268020) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in ICC/IF, IHC-Fr, IHC-P, WB in human, mouse, rat samples. Anti-Fibronectin antibody [EPR23110-46] (ab268020) has been cited over 46 times in peer reviewed journals and is trusted by the scientific community. Abcams high quality manufacturing and validation processes ensure Anti-Fibronectin antibody [EPR23110-46] (ab268020) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-Fibronectin antibody [EPR23110-46] (ab268020) has been confirmed by testing in knockout samples. Anti-Fibronectin antibody [EPR23110-46] (ab268020) specifically detects Fibronectin (UniProt ID: P02751; Molecular weight: 269kDa) and is sold in 100 uL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone EPR23110-46 - ab26822. Antibody clone EPR23110-46 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 594, Alexa Fluor® 568, Alexa Fluor® 555, Alexa Fluor® 647, Alexa Fluor® 488, Alexa Fluor® 75 ( ab3964 , ab3132 , ab313223 , ab31335 , ab314679 , ab321527 ). Fibronectin is a crucial extracellular matrix protein that significantly influences tumor development and progression by enhancing tumor growth, metastasis, and angiogenesis. It interacts with integrin receptors to help tumor cells adapt and survive in harsh microenvironments. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
IHC-P, IHC-Fr, ICC/IF, WB
Platform ID
BAB178536084
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin (PubMed : 3024962, PubMed : 3593230, PubMed : 3900070, PubMed : 7989369). Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (PubMed : 3024962, PubMed : 3593230, PubMed : 3900070, PubMed : 7989369). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation (PubMed : 34089617).. Anastellin. Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.. Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5 : ITGB1 integrin receptor signaling. See full target information FN1
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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