Anti-G3BP antibody [EPR13986(B)] - BSA and Azide free,Abcam,AB240247
ab240247 is the carrier-free version of ab181150 . Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies . Conjugation ready Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications. Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold. Compatibility This product is compatible with the Maxpar ® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar ® is a trademark of Fluidigm Canada Inc.
Host
Rabbit
Reactivity
Rat, Human, Mouse
Application
ICC/IF, WB, IHC-P, Flow Cyt (Intra), IP
Platform ID
BAB749363335
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Protein involved in various processes, such as stress granule formation and innate immunity (PubMed : 12642610, PubMed : 20180778, PubMed : 23279204, PubMed : 30510222, PubMed : 30804210). Plays an essential role in stress granule formation (PubMed : 12642610, PubMed : 20180778, PubMed : 23279204, PubMed : 32302570, PubMed : 32302571, PubMed : 32302572, PubMed : 34739333, PubMed : 35977029, PubMed : 36183834, PubMed : 36279435, PubMed : 36692217, PubMed : 37379838). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed : 12642610, PubMed : 20180778, PubMed : 23279204, PubMed : 27022092, PubMed : 32302570, PubMed : 32302571, PubMed : 32302572, PubMed : 36279435, PubMed : 37379838). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding : functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (PubMed : 32302570, PubMed : 32302571, PubMed : 32302572, PubMed : 34739333, PubMed : 36279435, PubMed : 36692217). Also acts as an ATP- and magnesium-dependent helicase : unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed : 9889278). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PubMed : 9889278). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PubMed : 9889278). Plays an essential role in innate immunity by promoting CGAS and RIGI activity (PubMed : 30510222, PubMed : 30804210). Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS (PubMed : 30510222). Triggers the condensation of cGAS, a process probably linked to the formation of membrane-less organelles (PubMed : 34779554). Enhances also RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA (PubMed : 30804210). May also act as a phosphorylation-dependent sequence-specific endoribonuclease in vitro : Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed : 11604510). See full target information G3BP1
Category Paths
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
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