Anti-GATA3 antibody [KT77],Abcam,AB110093

Host

Rat

Reactivity

Mouse

Application

WB, ICC/IF

Platform ID

BAB190130516

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-GATA3 antibody [KT77]
Cat. No.AB110093
HostRat
IsotypeIgG2a
ReactivityMouse
ApplicationWB, ICC/IF
ClonalityMonoclonal
Clone NumberKT77
Concentration1 mg/mL Batch dependent concentration
ImmunogenFull Length Protein corresponding to Mouse Gata3 phospho S308. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein G
Appearance/FormLiquid
ShippingBlue Ice
FormulationPreservative: 0.1% Sodium azide Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (PubMed : 31175139). Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages. See full target information Gata3

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