Anti-GBA3 antibody,Abcam,AB154897

Target data Neutral cytosolic beta-glycosidase with a broad substrate specificity that could play a role in the catabolism of glycosylceramides (PubMed : 11389701, PubMed : 11784319, PubMed : 17595169, PubMed : 20728381, PubMed : 26724485, PubMed : 33361282). Has a significant glucosylceramidase activity in vitro (PubMed : 17595169, PubMed : 26724485). However, that activity is relatively low and its significance in vivo is not clear (PubMed : 17595169, PubMed : 20728381, PubMed : 26724485). Hydrolyzes galactosylceramides/GalCers, glucosylsphingosines/GlcSphs and galactosylsphingosines/GalSphs (PubMed : 17595169). However, the in vivo relevance of these activities is unclear (PubMed : 17595169). It can also hydrolyze a broad variety of dietary glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens in vitro and could therefore play a role in the metabolism of xenobiotics (PubMed : 11784319). Possesses transxylosylase activity in vitro using xylosylated ceramides/XylCers (such as beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine) as xylosyl donors and cholesterol as acceptor (PubMed : 33361282). Could also play a role in the catabolism of cytosolic sialyl free N-glycans (PubMed : 26193330). See full target information GBA3