Anti-GBAS antibody [OTI1B8],Abcam,AB139357

Clone OTI1B8 (formerly 1B8).

Host

Mouse

Reactivity

Mouse, Rat, Dog, Human, African green monkey

Application

ICC/IF, WB, IHC-P

Platform ID

BAB502936619

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-GBAS antibody [OTI1B8]
Cat. No.AB139357
HostMouse
IsotypeIgG1
ReactivityMouse, Rat, Dog, Human, African green monkey
ApplicationICC/IF, WB, IHC-P
ClonalityMonoclonal
Clone NumberOTI1B8
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Full Length Protein corresponding to Human NIPSNAP2.
PurityAffinity purification
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Protein involved in mitophagy by facilitating recruitment of the autophagy machinery required for clearance of damaged mitochondria (PubMed : 30982665). Accumulates on the mitochondria surface in response to mitochondrial depolarization and acts as a 'eat me' signal by recruiting proteins involved in selective autophagy, such as autophagy receptors (CALCOCO2/NDP52, NBR1, SQSTM1/p62, TAX1BP1 and WDFY3/ALFY) and ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2) (PubMed : 30982665). See full target information NIPSNAP2

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