Anti-GBP4 antibody,Abcam,AB232689

Target data Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed : 24715728, PubMed : 24739961). Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product (PubMed : 9659399). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (PubMed : 24715728, PubMed : 24739961). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (PubMed : 24715728, PubMed : 24739961). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis, such as Gm12250/Irgb10 : this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (PubMed : 24715728, PubMed : 24739961). May play a role in erythroid differentiation (PubMed : 9659399). See full target information Gbp3