Anti-GFI1 antibody,Abcam,AB21061

Target data Transcription repressor essential for hematopoiesis (PubMed : 11060035, PubMed : 17197705, PubMed : 17646546, PubMed : 18805794, PubMed : 19164764, PubMed : 20190815, PubMed : 8754800). Functions in a cell-context and development-specific manner (PubMed : 11060035, PubMed : 17197705, PubMed : 17646546, PubMed : 18805794, PubMed : 19164764, PubMed : 20190815, PubMed : 8754800). Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes (PubMed : 11060035, PubMed : 17197705, PubMed : 17646546, PubMed : 18805794, PubMed : 19164764, PubMed : 20190815, PubMed : 8754800). Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed : 16287849). Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development (PubMed : 12778173). Inhibits SPI1 transcriptional activity at macrophage-specific genes, repressing macrophage differentiation of myeloid progenitor cells and promoting granulocyte commitment (By similarity). Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling (By similarity). Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA (PubMed : 20547752). Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth (PubMed : 19026687). Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters (PubMed : 16287849). Required for the maintenance of inner ear hair cells (By similarity). In addition to its role in transcription, acts as a substrate adapter for PRMT1 in the DNA damage response : facilitates the recognition of TP53BP1 and MRE11 substrates by PRMT1, promoting their methylation and the DNA damage response (PubMed : 29651020). See full target information GFI1