Anti-GM130 antibody - BSA and Azide free,Abcam,AB169276
What is this antibody validated in? Anti-GM130 antibody - BSA and Azide free (ab169276) is a mouse polyclonal antibody and is validated for use in Western Blot (WB), Immunocytochemistry/immunofluorescence (ICC/IF) in Human samples. What is the molecular weight of GM130? Anti-GM130 - BSA and Azide free (ab169276) specifically detects a band for GM130 (UniProt: Q08379) at a molecular weight of 112kDa. Trusted by the scientific community Anti-GM130 - BSA and Azide free (ab169276) was first used in a scientific publication in 2013 and has been cited over 30 times in peer-reviewed journals. Reviewed by scientists Anti-GM130 - BSA and Azide free (ab169276) has over 5 independent reviews from customers.
Host
Mouse
Reactivity
Human
Application
ICC/IF, WB
Platform ID
BAB383371509
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane (Probable) (PubMed : 16489344). Required for normal protein transport from the endoplasmic reticulum to the Golgi apparatus and the cell membrane (By similarity). Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly : phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization (PubMed : 26165940). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle : upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (PubMed : 19242490, PubMed : 26165940). Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization (PubMed : 18045989, PubMed : 19109421). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed : 16489344, PubMed : 17314401). See full target information Golgin subfamily A member 2
Category Paths
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