Anti-Galectin 3 antibody [A3A12],Abcam,AB2785

What is this antibody validated in? Anti-Galectin 3 antibody [A3A12] (ab2785) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse samples. What is the molecular weight of Galectin 3? Anti-Galectin 3 [A3A12] (ab2785) specifically detects a band for Galectin 3 (UniProt: P17931) at a molecular weight of 26kDa. Trusted by the scientific community Anti-Galectin 3 [A3A12] (ab2785) was first used in a scientific publication in 2003 and has been cited over 70 times in peer-reviewed journals. Reviewed by scientists Anti-Galectin 3 [A3A12] (ab2785) has over 15 independent reviews from customers.

Host

Mouse

Reactivity

Mouse, Human

Application

IHC-P, ICC/IF, WB

Platform ID

BAB188331380

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-Galectin 3 antibody [A3A12]
Cat. No.AB2785
HostMouse
IsotypeIgG1
ReactivityMouse, Human
ApplicationIHC-P, ICC/IF, WB
ClonalityMonoclonal
Clone NumberA3A12
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Full Length Protein corresponding to Human LGALS3.
PurityAffinity purification
Appearance/FormLiquid
ShippingBlue Ice
FormulationPreservative: 0.05% Sodium azide Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus : acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes. See full target information LGALS3

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