Anti-Gata6 antibody [EPR29847-53],Abcam,AB322895

Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rabbit

Reactivity

Human

Application

ICC/IF, ChIP-seq, WB, IHC-P, IP, ChIC/CUT&RUN-seq

Platform ID

BAB190230468

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Gata6 antibody [EPR29847-53]
Cat. No.AB322895
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationICC/IF, ChIP-seq, WB, IHC-P, IP, ChIC/CUT&RUN-seq
ClonalityMonoclonal
Clone NumberEPR29847-53
Concentration0.493 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Transcriptional activator (PubMed : 19666519, PubMed : 22750565, PubMed : 22824924, PubMed : 27756709). Regulates SEMA3C and PLXNA2 (PubMed : 19666519). Involved in gene regulation specifically in the gastric epithelium (PubMed : 9315713). May regulate genes that protect epithelial cells from bacterial infection (PubMed : 16968778). Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). In human skin, controls several physiological processes contributing to homeostasis of the upper pilosebaceous unit. Triggers ductal and sebaceous differentiation as well as limits cell proliferation and lipid production to prevent hyperseborrhoea. Mediates the effects of retinoic acid on sebocyte proliferation, differentiation and lipid production. Also contributes to immune regulation of sebocytes and antimicrobial responses by modulating the expression of anti-inflammatory genes such as IL10 and pro-inflammatory genes such as IL6, TLR2, TLR4, and IFNG. Activates TGFB1 signaling which controls the interfollicular epidermis fate (PubMed : 33082341). See full target information GATA6

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