Anti-Gli1 antibody [EPR4523],Abcam,AB134906

This antibody was developed as part of a collaboration with the lab of Martin Fernandez-Zapico at the Mayo Clinic. Species reactivity Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rabbit

Reactivity

Human

Application

WB

Platform ID

BAB193428932

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Gli1 antibody [EPR4523]
Cat. No.AB134906
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationWB
ClonalityMonoclonal
Clone NumberEPR4523
Concentration1.36 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Acts as a transcriptional activator (PubMed : 10806483, PubMed : 19706761, PubMed : 19878745, PubMed : 24076122, PubMed : 24217340, PubMed : 24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed : 2105456, PubMed : 24217340, PubMed : 8378770). Regulates the transcription of specific genes during normal development (PubMed : 19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed : 19706761, PubMed : 28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed : 11238441, PubMed : 28973407).. Isoform 2. Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. See full target information GLI1

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