Anti-Gli2 antibody [9HCLC],Abcam,AB277800

What are recombinant multiclonals? Recombinant multiclonals are a mixture of recombinant antibodies co-expressed from a library of heavy and light chains. They offer several advantages including: - The sensitivity of polyclonal antibodies by recognising multiple epitopes - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production View our range of recombinant multiclonal antibodies .

Host

Rabbit

Reactivity

Rat, Mouse, Human

Application

WB

Platform ID

BAB130947673

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Gli2 antibody [9HCLC]
Cat. No.AB277800
HostRabbit
IsotypeIgG
ReactivityRat, Mouse, Human
ApplicationWB
ClonalityMulticlonal
Clone Number9HCLC
Concentration0.5 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human GLI2 aa 1-350. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 Preservative: 0.09% Sodium azide Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Functions as a transcription regulator in the hedgehog (Hh) pathway (PubMed : 18455992, PubMed : 26565916). Functions as a transcriptional activator (PubMed : 19878745, PubMed : 24311597, PubMed : 9557682). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed : 15994174, PubMed : 20685856).. Isoform 1. Involved in the smoothened (SHH) signaling pathway.. Isoform 2. Involved in the smoothened (SHH) signaling pathway.. Isoform 3. Involved in the smoothened (SHH) signaling pathway.. Isoform 4. Involved in the smoothened (SHH) signaling pathway.. Isoform 1. Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed : 9557682).. Isoform 2. (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed : 9557682).. Isoform 3. (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed : 9557682).. Isoform 4. (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed : 9557682).. Isoform 5. Acts as a transcriptional repressor. See full target information GLI2

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