Anti-Gli2 antibody [OTI1F9],Abcam,AB187386

Target data Functions as a transcription regulator in the hedgehog (Hh) pathway (PubMed : 18455992, PubMed : 26565916). Functions as a transcriptional activator (PubMed : 19878745, PubMed : 24311597, PubMed : 9557682). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed : 15994174, PubMed : 20685856).. Isoform 1. Involved in the smoothened (SHH) signaling pathway.. Isoform 2. Involved in the smoothened (SHH) signaling pathway.. Isoform 3. Involved in the smoothened (SHH) signaling pathway.. Isoform 4. Involved in the smoothened (SHH) signaling pathway.. Isoform 1. Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed : 9557682).. Isoform 2. (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed : 9557682).. Isoform 3. (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed : 9557682).. Isoform 4. (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed : 9557682).. Isoform 5. Acts as a transcriptional repressor. See full target information GLI2