Anti-Granzyme B antibody,Abcam,AB4059
What is this antibody validated in? Anti-Granzyme B antibody (ab4059) is a rabbit polyclonal antibody and is validated for use in Immunohistochemistry (IHC-P) in Human samples. Trusted by the scientific community Anti-Granzyme B (ab4059) was first used in a scientific publication in 2003 and has been cited over 160 times in peer-reviewed journals. Reviewed by scientists Anti-Granzyme B (ab4059) has over 20 independent reviews from customers.
Host
Rabbit
Reactivity
Human
Application
IHC-P
Platform ID
BAB698576460
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse (PubMed : 1985927, PubMed : 3262682, PubMed : 3263427). It cleaves after Asp (PubMed : 1985927, PubMed : 8258716). Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death (PubMed : 31953257, PubMed : 32188940). Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -9 and -10 (CASP3, CASP9 and CASP10, respectively) to give rise to active enzymes mediating apoptosis (PubMed : 9852092). Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair (By similarity). See full target information GZMB
Category Paths
- Products>Primary Antibodies>Polyclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
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