Anti-H-ERG antibody,Abcam,AB196301

Target data Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel (PubMed : 10219239, PubMed : 10753933, PubMed : 10790218, PubMed : 10837251, PubMed : 11997281, PubMed : 12063277, PubMed : 18559421, PubMed : 22314138, PubMed : 22359612, PubMed : 26363003, PubMed : 27916661, PubMed : 9230439, PubMed : 9351446, PubMed : 9765245). Channel properties are modulated by cAMP and subunit assembly (PubMed : 10837251). Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization (PubMed : 10219239, PubMed : 10753933, PubMed : 10790218, PubMed : 10837251, PubMed : 11997281, PubMed : 12063277, PubMed : 18559421, PubMed : 22314138, PubMed : 22359612, PubMed : 26363003, PubMed : 27916661, PubMed : 9230439, PubMed : 9351446, PubMed : 9765245). Channel properties are modulated by cAMP and subunit assembly (PubMed : 10837251). Forms a stable complex with KCNE1 or KCNE2, and that this heteromultimerization regulates inward rectifier potassium channel activity (PubMed : 10219239, PubMed : 9230439).. Isoform A-USO. Has no inward rectifier potassium channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation.. Isoform B-USO. Has no inward rectifier potassium channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation. See full target information KCNH2