Anti-HDAC1 antibody - Nuclear Loading Control and ChIP Grade,Abcam,AB1767

Target data Catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed : 11571273, PubMed : 12408863, PubMed : 28245922). Histone deacetylation may constitute a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed : 11571273, PubMed : 15306652, PubMed : 15545624, PubMed : 8955276). For instance, deacetylation of histone H3 may be a prerequisite for the subsequent recruitment of the histone methyltransferase Su(var)3-9 to histones (PubMed : 11571273). Involved in position-effect variegation (PEV) (PubMed : 11571273). In the larval brain, part of a regulatory network including the transcriptional repressors klu, dpn and E(spl)mgamma-HLH which is required for type II neuroblast self-renewal and for maintaining erm in an inactive state in intermediate neural progenitors (INP) (PubMed : 28245922). See full target information HDAC1