Anti-HDAC10 antibody [EPR3576],Abcam,AB108934

Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies . Species reactivity Rat: We have preliminary internal testing data to indicate this antibody may not react with this species. Please contact us for more information.

Host

Rabbit

Reactivity

Human

Application

ICC/IF, Flow Cyt (Intra), IP, WB

Platform ID

BAB640093281

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-HDAC10 antibody [EPR3576]
Cat. No.AB108934
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationICC/IF, Flow Cyt (Intra), IP, WB
ClonalityMonoclonal
Clone NumberEPR3576
Concentration1.831 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed : 28516954). Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine (PubMed : 28516954). Histone deacetylase activity has been observed in vitro (PubMed : 11677242, PubMed : 11726666, PubMed : 11739383, PubMed : 11861901). Has also been shown to be involved in MSH2 deacetylation (PubMed : 26221039). The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed : 28516954). May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed : 23801752, PubMed : 29968769). May play a role in homologous recombination (PubMed : 21247901). May promote DNA mismatch repair (PubMed : 26221039). See full target information HDAC10

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